Nutritional Medicine , Separating Fact from Fiction
Most people have heard of resveratrol, the amazing anti-aging supplement so prevalent in the news. Recent research is moving quickly to show us that resveratrol may now play a role in becoming our next anti-obesity drug.
We often compare the metabolic effect from restricting calorie intake to be the relative “gold-standard” by which to judge other compounds as we seek for calorie-restriction mimetics. Obviously, calorie-restriction is not a realistic treatment to extend life, so we seek compounds that replicate the biochemical changes that occur during caloric restriction.
Studies in mice have shown mechanisms whereby resveratrol can act to mimic caloric restriction even when mice were fed a high fat diet (Barger, et al. 2008). Dietary resveratrol also mimics the effects of caloric restriction in insulin mediated glucose uptake in cells, thus posing a role in pre-diabetes and diabetes – two conditions typically found in the obese patient.
The wide scope of mechanisms of actions of resveratrol has shown shifts in metabolic and hormonal milieu that mimic the effects of reduced calorie intake even when calorie intake and/or fat intake are high. The findings of Barger, et al. showed an intake of resveratrol achievable in humans mimics caloric restriction at the gene expression level.
Thus, resveratrol may enhance the anti-obesity effects by mimicking the calorie restriction effects of low calorie diets, vasculature effects and those found when increasing aerobic capacity.
The more recent studies on humans have shown that a dosage of 60 - 150 mg once per day helped obese, but not normal weight; people lose more weight than those not supplemented with the resveratrol during weight loss treatments.
What is even more exciting is that resveratrol has the potential to interfere with leptin resistance brought on by some psychotropic medications thus promoting obesity resistant to treatment. Resveratrol may now be considered in study trials to interrupt or interfere with that metabolic train wreck currently caused by many drugs on the market.
Naderali, EK. 2009. Obesity and cardiovascular dysfunction: A role for resveratrol? Obesity Research & Clinical Practice; 3(1):45-52.
Barger, et.al. 2008. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice; 3(6):e2264.
Timmers S, Konings E, Bilet L., Houtkooper RH, Weijer T, Goossens GH, et. al.2011. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab; 14:612-622.
Franco J, Dias-Rocha C, Fernandes T,et al. 2015 Resveratrol treatment rescues hyperleptinemia and improves hypothalamic leptin signaling programmed by a maternal high-fat diet. European Journal of Nutrition. http://link.springer.com/article/10.1007%2Fs00394-015-0880-7
Tags: Resveratrol, Weight-Loss, Psychotropic Drugs, Weight-Gain, Hyperleptinemia